Mannitol for acute traumatic brain injury

P22: Traumatic Brain Injury

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The early response of mannitol infusion in traumatic brain injury.

INTRODUCTION Mannitol was used in traumatic brain injury but controversy about the onset and duration. SETTING Clinical observational study. METHODS Fourteen traumatic brain injured patients with a Glasgow Coma Scale (GCS) score < or = 8 were enrolled. Group I patients (n = 8) with intracranial pressure (ICP) < 20 mmHg, and group II patients (n = 6) with ICP > or = 20 mmHg underwent transcr...

Traumatic Brain Injury – Acute Care

Corticosteroids for acute traumatic brain injury.

BACKGROUND Traumatic brain injury is a leading cause of death and disability. Corticosteroids have been widely used in treating people with traumatic brain injury. OBJECTIVES To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury. SEARCH STRATEGY Electronic sources: MEDLINE, EMBASE, Cochrane Library and specialised database searches. Add...

Effects of Quercetin and Mannitol on Erythropoietin Levels in Rats Following Acute Severe Traumatic Brain Injury

OBJECTIVE The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model. METHODS A weight-drop impact acceleration model of TBI was used on 40 male Wistar rats. The animals were divided into sham (group I), TBI (group II), TBI+quercet...